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Given that inhibition of a single lysosomal enzyme takes time to alter a system such as the lysosomal pathway, the inhibition of glucocerebrosidase for several days appeared more relevant in LUHMES cells

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In the present study, intraperitoneal administration of MTX concomitantly with VPA resulted in significant increase in tissue catalase and tissue glutathione reductase with significant decrease in tumor volume, tissue MDA, tissue cholesterol and tissue TNF-α and alleviated the histopathological changes with significant increase in the expression of p53 and apoptotic index compared to the group that received subcutaneous implantation of Ehrlich tumor cells